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由(you)中(zhong)國(guo)科(ke)學院(yuan)蘇(su)州生物醫(yi)學工程技術研(yan)究(jiu)所承擔的國(guo)家重大科(ke)研(yan)裝(zhuang)備研(yan)制項目(mu)“超分(fen)辨顯(xian)微(wei)光(guang)學核心部件及系(xi)統研(yan)制”26日在蘇(su)州高新區(qu)通過(guo)驗收,標志著(zhu)我國(guo)已(yi)經成功研(yan)制出超分(fen)辨光(guang)學顯(xian)微(wei)鏡(jing)。

驗收專家組組長、中科院高(gao)能(neng)物(wu)(wu)理所柴(chai)之芳(fang)院士(shi)認(ren)為,該項目的成(cheng)功(gong)實(shi)施(shi),改善了我國光學(xue)顯微(wei)鏡基(ji)本依賴進(jin)口(kou)的狀(zhuang)況(kuang),對(dui)滿足我國生物(wu)(wu)醫學(xue)等前沿基(ji)礎研究的定制(zhi)化需求(qiu)、提升(sheng)創新能(neng)力,以及推動(dong)我國光學(xue)顯微(wei)鏡行業轉型升(sheng)級具有重要意義。

在當今生(sheng)物學(xue)和(he)基礎醫學(xue)研究(jiu)中,高(gao)/超(chao)分辨光學(xue)顯微鏡發揮著至(zhi)關重要(yao)的(de)作(zuo)用,10納(na)米至(zhi)100納(na)米尺度的(de)超(chao)分辨顯微光學(xue)成像更是取得原創性(xing)研究(jiu)成果的(de)重要(yao)手段(duan)。

歷時5年攻(gong)關(guan),中(zhong)科(ke)(ke)院蘇州醫工(gong)所科(ke)(ke)研人(ren)員(yuan)突破大數值(zhi)孔徑物鏡(jing)(jing)、特(te)種光(guang)(guang)(guang)源、新型納米熒光(guang)(guang)(guang)增強試(shi)劑、系統(tong)集成(cheng)(cheng)與檢測等關(guan)鍵技(ji)術，其中(zhong)獲得(de)授權30余項(xiang)；研制出激光(guang)(guang)(guang)掃描共聚焦顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)、雙(shuang)光(guang)(guang)(guang)子顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)、受激發(fa)(fa)射損耗(STED)超分辨(bian)顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)、雙(shuang)光(guang)(guang)(guang)子-STED顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)等光(guang)(guang)(guang)學(xue)顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)整(zheng)機；建成(cheng)(cheng)了顯(xian)(xian)(xian)微(wei)(wei)光(guang)(guang)(guang)學(xue)加工(gong)、裝調、檢測以及顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)整(zheng)機技(ji)術集成(cheng)(cheng)工(gong)程化(hua)平臺(tai),培養出一支(zhi)具備研制復雜精密光(guang)(guang)(guang)學(xue)顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)能力的研發(fa)(fa)團隊,為我(wo)國光(guang)(guang)(guang)學(xue)顯(xian)(xian)(xian)微(wei)(wei)鏡(jing)(jing)的發(fa)(fa)展提供了系統(tong)解決(jue)方(fang)案。

中(zhong)科院蘇州(zhou)醫(yi)工所所長唐玉國(guo)介紹,該所研(yan)制的超分辨顯微鏡(jing)(jing)或核心部件已在(zai)美國(guo)、德國(guo)、以(yi)色列及國(guo)內多(duo)家研(yan)究(jiu)機構投入使(shi)用(yong)(yong)并取(qu)得部分成果。例(li)如，中(zhong)科院動物(wu)所利(li)用(yong)(yong)光學(xue)顯微鏡(jing)(jing)觀察發育生(sheng)物(wu)學(xue)中(zhong)的基本現象,研(yan)究(jiu)潛在(zai)調(diao)控機制；中(zhong)科院藥物(wu)所應用(yong)(yong)光學(xue)顯微鏡(jing)(jing)觀察藥物(wu)胞(bao)內靶(ba)向定位和輸送,加速(su)創(chuang)新性新藥研(yan)發。